Endocrine Abstracts

Background: In obesity, excess nutrients and an increased demand for protein synthesis contribute to unfolded proteins accumulating within the endoplasmic reticulum and consequent activation of unfolded protein response (UPR). UPR in adipose tissue (AT) is critical to the initiation and integration of inflammation and insulin signalling pathways in obese and type 2 diabetes mellitus (T2DM) patients. The aim of this study was to examine whether novel malabsorptive or bypass bar...

Background: Endoplasmic reticulum (ER) stress in adipose tissue (AT) is critical to the initiation and integration of inflammation and insulin signalling pathways in obese and type 2 diabetes mellitus (T2DM) patients. It induces an unfolded protein response (UPR) to restore functional integrity which leads to upregulation of three master regulators of ER; PKR-like ER-regulated kinase (PERK), inositol requiring enzyme1α (IRE1α) and activating transcription factor6 (AT...